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Message 36975 - Posted: 31 May 2014 | 19:10:14 UTC

Hi all,

I have submitted a bunch of new workunits to the short queue. This should fix the dry spell we have had there for the past week.

The workunits are named "NATHAN_CMYBKIX". In these simulations I am investigating the binding of a small disodered protein named cMyb to another protein named KIX. Disordered proteins and disordered domains (as opposed to nicely structured ones like hemoglobin) are very important in protein-protein interactions. Mutations in disordered proteins are very common in cancers, amyloid fibril diseases like alzheimer's and parkinson's, and probably a lot of other disease we don't know about. So, with these simulations we will be taking some first steps towards understanding some key things about these types of interactions. Lessons we learn from this system should help us work on many, many others.

Nate

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Message boards : News : WU: CMYBKIX