At the end of last year, we updated the badge system to include several new publications we had just published. Today we want to highlight one of those pieces of work.
Starting in Mid-2011 (an eternity ago), we began collaborating with a research group in Italy to better understand something strange they had been seeing in their experiments. Specifically, they were seeing that when they modified the composition of lipids in a cell membrane, the activity of an enzyme named FAAH increased. They came to us to try to better understand why that was happening. Through simulations performed here on GPUGRID we discovered that, contrary to expectations, the lipids modified the function of the enzyme by directly interacting with it and its endogenous ligand. It had been expected that structural changes in the membrane would be the culprit, but that was not the case. Additionally, we report the first unbiased binding of a lipid to a membrane protein. This is one of the first experiments of this kind ever performed, and was possible only because of the compute power we have here at GPUGRID. You can read more about it on the science page here, as well as check out the video of the binding event.
Please note that (almost) all the papers we publish are available on our lab webpage. They can be found here. The versions of the documents there are the pre-print versions, basically meaning they are not formatted to look pretty. This is due to restrictions placed on us by the publishing companies. The text and figures are identical to those in the "pretty" version published in the journal, however. We are working on putting out copies of any papers missing from that page.
Lastly, we remind you that GPUGRID accepts donations beyond compute time, and if you're interested you can see how to do so on our Donations page. Of course, the crunching time donated by all of you is greatly appreciated.
Thanks and onward,
The GPUGRID Team