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Toni
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Message 24037 - Posted: 19 Mar 2012 | 15:02:58 UTC
Last modified: 19 Mar 2012 | 15:08:54 UTC

Dears!

We have recently published a new paper on the Journal of Chemical Theory and Computation: "Visualizing the Induced Binding of SH2-Phosphopeptide", authored by me, ignasi (shared co-authors) and GDF. In the paper we have made (hopefully :) good use of your donated GPU time to find out in detail what happens when a kind of signal is transmitted between proteins in a cell. The signal is the recognition of a short peptide (pYEEI for friends) by a partner "plug", called the SH2 domain. This kind of signaling is in fact very common in cells for responding to all varieties of messages (for example in receptor kinases).

We updated the badges accordingly - and this time we also briefly go down the hall of fame. Of the 3113 contributors, these are the 10 users who contributed the most computation (rank, name, millions of credits):

1 Retvari Zoltan 70.1
2 Venec 66.8
3 davidYuen 49.0
4 WirelessDude 46.8
5 Stoneageman 46.3
6 CTAPbIi 26.0
7 Helmholdt 24.8
8 Nikke 24.3
9 CNT - IQE 24.0
10 Ketzer7 24.0

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Message 24038 - Posted: 19 Mar 2012 | 16:47:53 UTC - in response to Message 24037.

Hi, congratulations to all !
I would like a link to this ranking ? Is it possible ?
Thanks in advance.
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(Martin Luther King)

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Message 24040 - Posted: 19 Mar 2012 | 18:02:34 UTC
Last modified: 19 Mar 2012 | 18:07:04 UTC

Yeay my first one :D

Is there a link to the published paper too?
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Crunching for my deceased Dog who had "good" Braincancer..

ignasi
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Message 24041 - Posted: 19 Mar 2012 | 18:14:23 UTC - in response to Message 24040.

I would like a link to this ranking ? Is it possible ?


No, the rankings aren't on the web.

Yeay my first one :D

Is there a link to the published paper too?


Here you'll find it.

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Message 24042 - Posted: 19 Mar 2012 | 18:55:07 UTC - in response to Message 24037.

Wow!
Finally I've got my own personal Chuck Norris badge :)

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Message 24043 - Posted: 19 Mar 2012 | 19:25:06 UTC - in response to Message 24042.

The signal is the recognition of a short peptide (pYEEI for friends) by a partner "plug", called the SH2 domain. This kind of signaling is in fact very common in cells for responding to all varieties of messages (for example in receptor kinases).

After watching the video now I understand this statement perfectly! :o)

Finally I've got my own personal Chuck Norris badge :)

Congrats! Surprised? You get more credit in one day than me in one month!


JLConawayII
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Message 24048 - Posted: 20 Mar 2012 | 3:46:10 UTC - in response to Message 24042.

Wow!
Finally I've got my own personal Chuck Norris badge :)



Congratulations, but it doesn't make up for the extraordinarily unfortunate shape of that lysine badge. ^^

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Message 24052 - Posted: 20 Mar 2012 | 11:08:33 UTC - in response to Message 24048.

Congratulations, but it doesn't make up for the extraordinarily unfortunate shape of that lysine badge. ^^

:) See this video from 2:03 and 2:22

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Message 24053 - Posted: 20 Mar 2012 | 13:23:42 UTC - in response to Message 24052.

The signal is the recognition of a short peptide (pYEEI for friends) by a partner "plug", called the SH2 domain. This kind of signaling is in fact very common in cells for responding to all varieties of messages (for example in receptor kinases).

After watching the video now I understand this statement perfectly! :o)

Just look at the surface changes (red) and you will appreciate how much the SH2 domain alters when pYEEI binds to the domain. Red and blue are commonly used to indicate hydrophobic and hydrophilic areas.
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ignasi
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Message 24055 - Posted: 20 Mar 2012 | 14:20:50 UTC - in response to Message 24053.

Red and blue are commonly used to indicate hydrophobic and hydrophilic areas.


Good point. Indeed, red and blue often indicate hydrophilic (electrically charged) regions or hydrophobic (greasy) ones.
However, in this very video red and blue indicate the fluctuation of the position of the atoms, that is for example, their vibration. So, if you pay attention, as the ligand (the skinny nervous fella) binds to his big buddy, goes from red to blue meaning that it reagidifies. And so happens in some degree for the big buddy (SH2 protein). It even partially hugs it from the left at 1:15...

cheers

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Message 24057 - Posted: 20 Mar 2012 | 16:49:43 UTC

congrats to all !
good work !
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Message 24059 - Posted: 20 Mar 2012 | 20:45:52 UTC

http://pubs.acs.org/toc/jctcce/0/0
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Message 24122 - Posted: 24 Mar 2012 | 1:20:17 UTC

Thx :-) I hope this will help you, guys.
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Message 25492 - Posted: 4 Jun 2012 | 16:37:25 UTC

Just realized i'm in top 25% of contributors in this one ( 346/3113 ) - cool :-)
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Message 25576 - Posted: 8 Jun 2012 | 15:15:47 UTC - in response to Message 24042.

Wow!
Finally I've got my own personal Chuck Norris badge :)

Congrats!! I can just hear it now - "Chuck Norris Approved." LOL
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Message 25578 - Posted: 8 Jun 2012 | 19:12:47 UTC - in response to Message 24037.

All well and good but as far as I can tell it doesn't bring us one step closer to understanding that universal mystery...

...women!

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Message 25584 - Posted: 8 Jun 2012 | 21:54:15 UTC - in response to Message 25578.
Last modified: 8 Jun 2012 | 21:58:40 UTC

All well and good but as far as I can tell it doesn't bring us one step closer to understanding that universal mystery...

...women!

“Women are meant to be loved, not to be understood.”
― Oscar Wilde, Lord Arthur Savile's Crime and Other Stories

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Message 25623 - Posted: 11 Jun 2012 | 14:51:14 UTC

=) =) =)
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Crunching for my deceased Dog who had "good" Braincancer..

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Message boards : News : New publication, new badges!